HA15 是一种高效特异性内质网伴侣蛋白BiP/GRP78/HSPA5抑制剂，抑制 BiP 的 ATP 酶活性，具有抗肿瘤活性。

HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors.

HA15 induces ER stress leading to cancer cell death in vitro and overcomes BRAF inhibitor resistance in melanoma cells[1].

HA15 induces ER stress leading to cancer cell death and exhibits strong efficacy in xenograft mouse models with melanoma cells either sensitive or resistant to BRAF inhibitors[1].

1609402-14-3

C23H22N4O3S2

466.57

H2O:<1 mgml
DMSO:86 mg/mL (184.3 mM)
Ethanol:42 mg/mL (90 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years