SNX0723 是一种 HSP90 抑制剂，具有抗疟原虫活性。SNX0723 对 HsHSP90 和 PfHSP90 具有高结合亲和力，Ki 分别为 4.4 和 47 nM。SNX0723 抑制肝期伯氏疟原虫 ANKA 寄生虫，EC50 为 3.3 μM。

SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity. SNX0723 shows high binding affinity for HsHsp90 and PfHsp90 with Kis of 4.4 and 47 nM, respectively. SNX0723 inhibits liver-stage P. berghei ANKA parasites with the EC50 of 3.3 μM.

SNX0723 inhibits P. falciparum Dd2 blood-stage parasites and P. berghei ANKA liver-stage parasites, EC50 are 7.4μM and 6.5μM, respectively[1].

1073969-18-2

C22H26FN3O3

399.46

SNX 0723;SNX- 0723

DMSO:18.9mg/mL (47.3mM),ultrasonic and warming and heat to 60°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years