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Benzthiazide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:91-33-8
包装与价格:
包装价格(元)
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Dihydrex
Aquatag
Lemazide
苄噻嗪
产品介绍
Benzthiazide 是长效利尿剂及抗高血压剂。它也是碳酸酐酶 9 的抑制剂,他对 CA9,CA2 和 CA1 的Ki分别为 8.0,8.8 和 10 nM。它对肿瘤细胞增殖具有抑制作用。

产品描述

Benzthiazide is used in the therapy of edema and hypertension. Like other thiazides, benzthiazide accelerates water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.

Cas No.

91-33-8

分子式

C15H14ClN3O4S3

分子量

431.94

别名

Dihydrex;Aquatag;Lemazide;苄噻嗪

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years