您好，欢迎来到试剂仪器网！ [登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > Boc-NH-O-C1-NHS ester
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Boc-NH-O-C1-NHS ester
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Boc-NH-O-C1-NHS ester图片
CAS NO:80366-85-4
包装与价格：
包装价格(元)
250mg电议
500mg电议

产品介绍
Boc-NH-O-C1-NHSester是一种PROTAClinker，属于alkyl/ether类。可用于合成PROTAC分子。
Cas No.80366-85-4
别名[(叔丁氧羰基)氨基氧]乙酸N-琥珀酰亚胺酯
Canonical SMILESO=C1CCC(N1OC(CONC(OC(C)(C)C)=O)=O)=O
分子式C11H16N2O7
分子量288.25
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Boc-NH-O-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562