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yGsy2p-IN-H23
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
yGsy2p-IN-H23图片
CAS NO:1269190-98-8
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
yGsy2p-IN-H23是一种有效的酵母糖原合酶2(yGsy2p)抑制剂,对人糖原合酶1(hGYS1)的IC50为875µM。yGsy2p-IN-H23结合在yGsy2p的尿苷二磷酸葡萄糖结合口袋内。yGsy2p-IN-H23用于糖原储存疾病(GSDs)的相关研究。
Cas No.1269190-98-8
Canonical SMILESOC1=CC=C(C2=C(C3=CC=CC=C3)N=CN2CCC4N(C)CCC4)C=C1OC
分子式C23H27N3O2
分子量377.48
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

yGsy2p-IN-H23 is a potent and first-in-class inhibitor for yeast glycogen synthase 2 (yGsy2p) with an IC50 of 875 µM for human glycogen synthase 1 (hGYS1). yGsy2p-IN-H23 bounds within the uridine diphosphate glucose binding pocket of yGsy2p. yGsy2p-IN-H23 is used for the research of glycogen storage diseases (GSDs)[1].

yGsy2p-IN-H23 (compound H23) has IC50 values against either hGYS1δ634S8,11N or wild-type hGYS1 were 161 μM and 875 µM, respectively. yGsy2p-IN-H23 exhibits IC50 values of 280 µM and 263 µM in the absence and presence of G6P for yGsy2p against yeast and human glycogen synthase (GS), respectively. yGsy2p-IN-H23 is not in direct competition with G6P[1].

[1]. Buyun Tang, et al. Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase. J Med Chem. 2020 Apr 9;63(7):3538-3551.