| CAS NO: | 34188-11-9 |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 500mg | 电议 |
| Cas No. | 34188-11-9 |
| 别名 | 氨基-五聚乙二醇 |
| Canonical SMILES | OCCOCCOCCOCCOCCN |
| 分子式 | C10H23NO5 |
| 分子量 | 237.29 |
| 溶解度 | DMSO: 100 mg/mL (421.43 mM) |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. [1]. Nathanael Gray, et al. Bifunctional molecules for degradation of egfr and methods of use. WO2017185036A1. [2]. Nianhe Han, et al. Derivatives of dolastatin 10 and uses thereof. WO2016192527A1. |
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