| CAS NO: | 302939-48-6 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 302939-48-6 |
| Canonical SMILES | O=C(NC1=C(C2=C(CCCC2)S3)C3=NC=N1)C4=CC=CC=C4Br |
| 分子式 | C17H14BrN3OS |
| 分子量 | 388.28 |
| 溶解度 | DMSO: 250 mg/mL (643.87 mM) |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 has no stabilizing effect on CRY2. KL201 lengthens the period of circadian rhythms in cells and tissues[1]. KL201 causes dose-dependent lengthening of circadian period in Bmal1-dLuc reporter cells, and in cells with another circadian reporter Per2-dLuc. KL201 suppresses the intensity of Per2-dLuc reporter much more than that of Bmal1-dLuc, without affecting cellular viability[1].KL201 binds to CRY1 in overlap with FBXL3, a subunit of ubiquitin ligase complex, and the effect of KL201 is blunted by knockdown of FBXL3[1].KL201 lengthened circadian period and suppressed the intensity of Per2::Luc knockin reporter in mouse lung primary explants[1]. [1]. Simon Miller, et al. An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals. Cell Chem Biol. 2020 Sep 17;27(9):1192-1198.e5. |
m.cnreagent.com