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NH2-PEG2-CH2-Boc
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
NH2-PEG2-CH2-Boc图片
CAS NO:1948273-09-3
包装与价格：
包装价格(元)
100mg电议
250mg电议

产品介绍
NH2-PEG2-CH2-Boc是一种PROTAClinker，属于PEG类。可用于合成PROTAC分子。
Cas No.1948273-09-3
别名2-(3-(2-氨基乙氧基)丙氧基)乙酸叔丁酯
Canonical SMILESO=C(OC(C)(C)C)COCCCOCCN
分子式C11H23NO4
分子量233.3
溶解度DMSO: 150 mg/mL (642.95 mM); Water: 20 mg/mL (85.73 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NH2-PEG2-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562