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Methyltetrazine-PEG4-maleimide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Methyltetrazine-PEG4-maleimide图片
CAS NO:1802908-02-6
包装与价格:
包装价格(元)
10mg电议
25mg电议
100mg电议

产品介绍
Methyltetrazine-PEG4-maleimide是一种PROTAClinker,属于PEG类。可用于合成PROTAC分子。
Cas No.1802908-02-6
Canonical SMILESO=C(NCCOCCOCCOCCOC1=CC=C(C2=NN=C(C)N=N2)C=C1)CCN3C(C=CC3=O)=O
分子式C24H30N6O7
分子量514.53
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Methyltetrazine-PEG4-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562