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Azido-PEG8-Boc
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Azido-PEG8-Boc图片
CAS NO:1623791-99-0
包装与价格:
包装价格(元)
100mg电议
500mg电议

产品介绍
Azido-PEG8-Boc是一种PROTAClinker,属于PEG和Alkyl/ether类,可用于合成PROTAC。
Cas No.1623791-99-0
别名叠氮-八聚乙二醇-丙酸叔丁酯
Canonical SMILESO=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]
分子式C23H45N3O10
分子量523.62
溶解度DMSO: 200 mg/mL (381.96 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Azido-PEG8-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. Garofalo, Antonio, et al. Efficient synthesis of small-sized phosphonated dendrons: potential organic coatings of iron oxide nanoparticles. New Journal of Chemistry (2014), 38(11), 5226-5239.