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Mal-C2-cyclohexylcarboxyl-hydrazide hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mal-C2-cyclohexylcarboxyl-hydrazide hydrochloride图片
CAS NO:174422-72-1
包装与价格:
包装价格(元)
50mg电议
100mg电议

产品介绍
Mal-C2-cyclohexylcarboxyl-hydrazidehydrochloride是一种PROTAClinker,属于alkylchain类。可用于合成PROTAC分子。
Cas No.174422-72-1
别名MAL-C2-环己基羧基酰肼(盐酸盐)
Canonical SMILESCl[H].O=C1C=CC(N1CC(CC2)CCC2C(NN)=O)=O
分子式C12H18ClN3O3
分子量287.74
溶解度DMSO: 16.67 mg/mL (57.93 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Mal-C2-cyclohexylcarboxyl-hydrazide hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562