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N,N'-Dimethylthiourea
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
N,N'-Dimethylthiourea图片
CAS NO:534-13-4
包装:500mg
市场价:450元

产品介绍
N,N'-Dimethylthiourea(DMTU)是从黑蒜中分离出来的，是口服有效的羟基自由基(•OH)的清除剂，通过活化的中性粒细胞在体外阻止•OH的产生。N,N'-Dimethylthiourea通过发挥抗氧化作用，包括•OH清除和抗炎作用，防止水浸限制应激(WIRS)诱导的大鼠胃粘膜损伤。
Cas No.534-13-4
别名N,N-二甲基硫脲; DMTU
Canonical SMILESS=C(NC)NC
分子式C3H8N2S
分子量104.17
储存条件4℃, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

N,N'-Dimethylthiourea (DMTU), isolated from Allii Sativi Bulbus, is an orally active scavenger of hydroxyl radical (•OH) and blocks •OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including •OH scavenging and anti-inflammatory action[1][2].

N,N'-Dimethylthiourea (DMTU; 1, 2.5, or 5 mmol/kg; orally) administered at 0.5 h before the onset of WIRS reduces the severity of gastric mucosal lesions with attenuation of the changes in the levels of gastric mucosal MPO, pro-inflammatory cytokines, LPO, NOx, nonprotein SH, and vitamin C and gastric adherent mucus found at 3 h after the onset of WIRS in a dose-dependent manner in Male Wistar rats aged 6 weeks[1].

[1]. Yoshiji Ohta, et al. Protective effect of N,N'-dimethylthiourea against stress-induced gastric mucosal lesions in rats. Fundam Clin Pharmacol. 2017 Jun;31(3):319-328. [2]. Zhongyi Zhang, et al. Analysis of volatile compounds in fermented black garlic by GC-MS.