Licoflavone A 是分离自甘草根的黄酮类化合物,可以抑制酪氨酸磷酸酶 1B 的活性,IC50为 54.5 μM。
产品描述
Licoflavone A is a natural product isolated from the roots of Glycyrrhiza uralensis.
体外活性
Two new 2-arylbenzofurans, glycybenzofuran (1) and cyclolicocoumarone (2), together with 10 known flavonoids including licocoumarone (3), glycyrrhisoflavone (4), glisoflavone (5), cycloglycyrrhisoflavone (6), isoliquiritigenin (7), Licoflavone A (8), apigenin (9), isokaempferide (10), glycycoumarin (11), and isoglycycoumarin (12), were isolated from the roots of Glycyrrhiza uralensis and their structures were determined by extensive spectroscopic analyses. Compounds 1 and 5 showed significant protein tyrosine phosphatase-1B (PTP1B) inhibitory activity in vitro with the IC50 values of 25.5 and 27.9 μM, respectively.
Cas No.
61153-77-3
分子式
C20H18O4
分子量
322.35
储存和溶解度
H2O:< 0.1 mg/mL (insoluble)
DMSO:100 mg/mL (310.22 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years