(-)-EpigalloCATechin Gallate是茶类黄酮，具有强大的抗氧化，抗炎和抗癌作用。它可抑制EGFR信号传导，有抗癌作用。它是谷氨酸脱氢酶 1/2 抑制剂。它通过激活细胞色素c氧化酶来诱导氧化磷酸化。

Epigallocatechol Gallate(EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. EGCG is a phenolic antioxidant found in a number of plants such as green and black tea. It inhibits cellular oxidation and prevents free radical damage to cells.

Epigallocatechol Gallate (5 and 20 mg/kg, p.o.) inhibits the growth of tumor in the subcutaneous orthotopic transplant model[4].

LoVo, SW480, HCT-8, and HT-29 cells are seeded in 96-well plates at a concentration of 5×103?cells; each cell line is totally seeded in the 12 wells. Complete medium is added to the wells, up to 200 μL; the medium contains 0 μg/mL, 10 μg/mL, 20 μg/mL, and 35 μg/mL of epigallocatechol gallate. The inhibition rate=[1 - (absorbance of Epigallocatechol Gallate group - absorbance of control group)/(absorbance of control group - absorbance of blank control group)] × 100.

989-51-5

C22H18O11

458.375

EGCG;Epigallocatechol Gallate;(-)-表没食子儿茶素没食子酸酯

H2O:4.6 mg/mL (10 mM)
Ethanol:45.8 mg/mL (100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years