MPP+ iodide 是一种 5-羟色胺转运体的高亲和力底物，也是一种神经毒素 MPTP 的有毒代谢物，通过选择性破坏黑质多巴胺能神经元，在动物模型中引起帕金森病症状。它被多巴胺转运体吸收进入多巴胺能神经元，通过影响呼吸链复合体 I 对线粒体发挥神经毒性作用。

MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. MPP+ induces autophagic cell death in SH-SY5Y cells.

SH-SY5Y cells were treated with MPP+, mimicking the progress of dopaminergic neurons loss in PD. MPP+ (1-3 mM; 24 hours) remarkably decreases the viability of cells in both dose-dependent (1, 2, 3 mM for 24 h) and time dependent (1 mM) manner.[1]. MPP+ also inhibits the activity of nicotinamide adenosine dinucleotide (NADH)-linked respiration in mitochondrial preparations and impairs aerobic glycolysis, leading to the present belief that the inhibition of NADH-linked cell respiration may constitute the final molecular mechanism of MPP+ neurotoxicity[3].

36913-39-0

C12H12IN

297.139

H2O:100 mg/mL (336.54 mM),Need ultrasonic
DMSO:62.5 mg/mL (210.34 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years