CintiRORgon 是一种首创的、口服有活力的的RORγ选择性激动剂。它通过调节 RORγ 表达的 T 淋巴免疫细胞的基因表达，提高效应子功能，降低免疫抑制，抑制肿瘤生长，提高生存率。

Cintirorgon is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.

Upon oral administration of Cintirorgon, this agent selectively binds to the nuclear receptor transcription factor RORγ, forming a receptor complex that translocates to the nucleus, and binds to ROR response elements (ROREs), enhancing the function, proliferation and survival of type 17 T cells, including Th17 (helper T cells) and Tc17 (cytotoxic T cells). RORγ, the nuclear receptor transcription factor that is involved in Th17/Tc17 differentiation, plays a key role in immune activation.

2055536-64-4

C27H23F6NO6S

603.53

LYC-55716

DMSO:110 mg/mL (182.26 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years