Endoxifen 是 Tamoxifen 的关键活性代谢物，能抑制芳香酶的活性，与雌激素受体有较高的亲和力和特异性。它有潜力研究乳腺癌。

(E/Z)-Endoxifen is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-estrogen, as it has an approximately 100-fold greater affinity for estrogen receptors than tamoxifen. As the efficient conversion of tamoxifen to endoxifen depends on CYP2D6, polymorphisms in this CYP isoform can impact the effectiveness of TMX treatment.

110025-28-0

C25H27NO2

373.496

(E/Z)-Endoxifen;N-去甲基-4-羟基-;(E/Z)-N-desmethyl-4-hydroxy Tamoxifen

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years