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N-Desmethyl Sildenafil
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N-Desmethyl Sildenafil图片
CAS NO:139755-82-1
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品名称
Desmethylsildenafil
UK-103,320
产品介绍
N-Desmethyl Sildenafil是 Sildenafil 的主要代谢物。Sildenafil 是一种有效的 5 型磷酸二酯酶 (PDE5) 抑制剂。

产品描述

N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor.

体外活性

N-Desmethyl Sildenafil increases the amplitude of electroretinogram (ERG) recorded from the dark-adapted isolated rat retina, most probably through the enhancement of the photoreceptor cell response[1]. The formation of N-Desmethyl Sildenafil is examined using CYP3A supersomes co-expressing human P450 oxidoreductase and cytochrome b5. N-Desmethyl Sildenafil is catalyzed by CYP3A4, CYP3A5, and to a lesser extent by CYP3A7[2].

Cas No.

139755-82-1

分子式

C21H28N6O4S

分子量

460.55

别名

Desmethylsildenafil;UK-103,320

储存和溶解度

DMF:5 mg/mL
DMSO:PBS (pH 7.2)(1:5):0.15 mg/mL
DMSO:225mg/mL (488.5mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years