4-Methylamino antipyrine 是 Metamizole 的活性代谢产物,可用于疼痛和发烧的研究。Metamizole 是吡唑啉酮类非甾体抗炎药,可抑制COX。
产品描述
4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak anti-inflammatory properties.
体外活性
At room temperature and in an atmosphere with oxygen, Metamizole is spontaneously, nonenzymatically converted to 4-Methylamino antipyrine. Subsequently, the N-methyl side chain of 4-Methylamino antipyrine is oxidized to yield 4-formylaminoantipyrine, which is further converted to 4-aminoantipyrine [2].
体内活性
Eight healthy male piglets are administered Metamizole (100 mg/kg) intramuscularly. 4-Methylamino antipyrine plasma concentrations are quantitatively detectable from 0.25 to 48 h. The average maximum concentration of 4-Methylamino antipyrine is 47.59 mg/mL. The average half-lives is 8.57 h for 4-Methylamino antipyrine [1].
Cas No.
519-98-2
分子式
C12H15N3O
分子量
217.27
储存和溶解度
DMSO:49 mg/mL (225.52 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years