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CLOZAPINE N-OXIDE
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CLOZAPINE N-OXIDE图片
CAS NO:34233-69-7
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
氯氮平N-氧化
氯氮平N-氧化物
产品介绍
Clozapine N-oxide 是 Clozapine 的主要代谢产物,也是人毒蕈碱设计受体 (DREADDs) 激动剂。它可穿过血脑屏障,可激活DREADD受体hM3Dq和hM4Di。它是一种多巴胺拮抗剂,也是一种选择性毒蕈碱 M4 受体激动剂,EC50为 11 nM。

产品描述

Clozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration [1]. It is produced by the action of cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4, whose activities, in turn, can be affected by drugs and disease [2]. Clozapine N-oxide is normally biologically inactive. However, it can be used in designer receptor exclusively activated by designer drugs, also known as DREADDs, technology to modulate synthetic receptors in vivo [3].

Cas No.

34233-69-7

分子式

C18H19ClN4O

分子量

342.83

别名

氯氮平N-氧化;氯氮平N-氧化物

储存和溶解度

H2O:1 mg/mL
Ethanol:10 mg/mL
DMSO:6 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years