Genz-123346 free base 是一种能够阻断神经酰胺向GL1转化的GL1合酶的抑制剂，其抑制GM1的IC50值为14 nM。

Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.

GLPG-1690 was able to cause a sustained reduction of LPA levels in plasma in vivo and was shown to be efficacious in a bleomycin-induced pulmonary fibrosis model in mice and in reducing extracellular matrix deposition in the lung while also reducing LPA 18:2 content in bronchoalveolar lavage fluid.

491833-30-8

C24H38N2O4

418.578

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years