T863 是口服有效的二酰基甘油酰基转移酶1 选择性抑制剂。T863结合DGAT1的酰基辅酶A结合位点，抑制三酰甘油在细胞内的合成。

T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. IC50 value: Target: DGAT1 T863 causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice.

701232-20-4

C22H26N4O3

394.47

DGAT-3;DGAT-1 inhibitor

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years