(-)-p-Bromotetramisole Oxalate 是一种强效的、非特异性碱性磷酸酶抑制剂。

p-Bromotetramisole Oxalate is a potent and non-specific inhibitor of alkaline phosphatase.

Aurora A Inhibitor I is a 2,4-dianilinopyrimidine that selectively and potently inhibits Aurora A. Aurora A Inhibitor I effectively inhibits the proliferation of HCT116 and HT29 cells, with IC50 of 190 nM and 2.9 μM, respectively. The Aurora A selectivity of Aurora A Inhibitor I against Aurora B depends on a single amino acid (Thr217) of Aurora A. [1] In KCL-22 cells, Aurora A Inhibitor I (1-5 μM) increases G2/M cell fraction, induces histone H3 serine 10 phosphorylation, and suppresses mitotic Aurora A autophosphorylation on Thr288. Aurora A Inhibitor I (0.5-5 μM) also suppresses cell proliferation in KCL-22 cells, as well as BCR-ABL-negative leukemia cell lines KG-1 and HL-60. Aurora A Inhibitor I effectively induces apoptosis in KCL-22 cells at 5 μM. [2] In a recent study, Aurora A Inhibitor I is also found to inhibit cell growth of HCT116, HT29, and HeLa cells, with IC50 of 377.6 nM, 5.6 μM, and 416 nM. [3]

62284-79-1

C13H13BrN2O4S

373.22

6-Bromolevamisole oxalate;(-)-p-Bromolevamisole oxalate;(-)-对溴四咪唑草酸盐;L-p-Bromotetramisole oxalate

DMSO:69 mg/mL (184.9 mM)
H2O:28 mg/mL (75 mM)
Ethanol:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years