CAS NO: | 607742-69-8 |
规格: | ≥98% |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
500mg | 电议 |
1g | 电议 |
Molecular Weight (MW) | 353.44 |
---|---|
Formula | C19H19N3O2S |
CAS No. | 607742-69-8 |
Storage | -20℃ for 3 years in powder form |
-80℃ for 2 years in solvent | |
Solubility (In vitro) | DMSO: 78 mg/mL (220.7 mM) |
Water: <1 mg/mL | |
Ethanol: 2 mg/mL (5.7 mM) | |
Solubility (In vivo) | 2% DMSO, 48% PEG300, 2% Tween 80 and 48% water: 5mg/mL |
Synonyms | GSK 742457; GSK-742457; RVT-101; SB742457; SB 742457; GSK742457; SB-742457; RVT 101; RVT101 |
In Vitro | In vitro activity: SB-742457 is a selective 5-HT6 receptor antagonist with cognition, memory, and learning-enhancing effects. SB-742457 is a novel cognitive enhancing agent for Alzheimer's disease. SB-742457 is a potential agent added to stablize donepezil treatment in subjects with mild-to-moderate Alzheimer's disease. |
---|---|
In Vivo | SB-742457 is a potent and selective 5-HT6 receptor antagonist that is shown to reverse a scopolamine induced learning deficit in the novel object recognition test and to enhance performance in a water maze task by aged rats. |
Animal model | N/A |
Formulation & Dosage | N/A |
References | Neurotherapeutics. 2008 Jul;5(3):458-69. |