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Intepirdine(SB-742457 GSK-742457 RVT-101)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Intepirdine(SB-742457 GSK-742457 RVT-101)图片
CAS NO:607742-69-8
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)353.44
FormulaC19H19N3O2S
CAS No.607742-69-8
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 78 mg/mL (220.7 mM)
Water: <1 mg/mL
Ethanol: 2 mg/mL (5.7 mM)
Solubility (In vivo)2% DMSO, 48% PEG300, 2% Tween 80 and 48% water: 5mg/mL
SynonymsGSK 742457; GSK-742457; RVT-101; SB742457; SB 742457; GSK742457; SB-742457; RVT 101; RVT101
实验参考方法
In Vitro

In vitro activity: SB-742457 is a selective 5-HT6 receptor antagonist with cognition, memory, and learning-enhancing effects. SB-742457 is a novel cognitive enhancing agent for Alzheimer's disease. SB-742457 is a potential agent added to stablize donepezil treatment in subjects with mild-to-moderate Alzheimer's disease.

In VivoSB-742457 is a potent and selective 5-HT6 receptor antagonist that is shown to reverse a scopolamine induced learning deficit in the novel object recognition test and to enhance performance in a water maze task by aged rats.
Animal modelN/A
Formulation & DosageN/A
References

Neurotherapeutics. 2008 Jul;5(3):458-69.