| CAS NO: | 21306-65-0 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 21306-65-0 |
| 别名 | S-[4-(苄氧基)苯基]-S-甲基-N-(对甲苯基磺酰基)-硫亚胺,Triphenyl Compound A |
| Canonical SMILES | O=[S](/N=[S](C(C=C1)=CC=C1OCC2=CC=CC=C2)\C)(C(C=C3)=CC=C3C)=O |
| 分子式 | C21H21NO3S2 |
| 分子量 | 399.53 |
| 溶解度 | DMSO : 250 mg/mL (625.74 mM) |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | TPh A (Triphenyl Compound A) is a potent inhibitor of the nuclear protein pirin and binds specifically to pirin with a Ki of 0.6 uM. TPh A disrupts the formation of the bcl3-pirin complex. TPh A can be used as a novel small molecule tool to regulate pirin in cells[1]. The Pirin is a nuclear protein with the nuclear factor I/CCAAT box transcription factor (NFI/CTF). Pirin proteins are highly conserved between mammals, plants, fungi, and prokaryotic organisms and are considered to belong to the cupin superfamily.TPh A (20 µM; 5 hours) reduces the amount of pirin-bound Bcl3 and inhibits the interaction between pirin and Bcl3 in HEK293T cells in a glutathione S-transferase (GST) pulldown assay (HEK293T cells are transfected with vectors that encoded bcl3-Myc and pirin-His6 for 43 h of transfection)[1].TPh A (0-100 µM; 48 hours) does not exert any potent cytotoxic activity against many human cancer cell lines, it against MCF7, MDA-MB231, HeLa, DU145, HepG2, A549, HT1080, WM266-4, and SK-MEL-28 cells with IC50 values >50 µM, and exhibits IC50 values of 27 µM, 20 µM and 26 µM for PC3 HL60 and HT29 cells, respectively[1].TPhA (0-50 µM; 48 hours) inhibits cell migration in WM266-4 cells, SK-MEL-28 cell in a concentration-dependent manner[1]. References: |
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