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Azido-PEG8-NHS ester
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Azido-PEG8-NHS ester图片
CAS NO:1204834-00-3
包装:100mg
市场价:1800元

产品介绍
Azido-PEG8-NHS ester 是一种可降解 (cleavable) 的含 8 个单元 PEG 的 ADC linker,可用于合成抗体偶联药物 (ADC)。Azido-PEG8-NHS ester 也是一种 PROTAC linker,属于 PEG 和 Alkyl/ether 类,可用于合成 PROTAC 分子。
Cas No.1204834-00-3
Canonical SMILESO=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]
分子式C23H40N4O12
分子量564.58
溶解度DMSO : 100 mg/mL (177.12 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Azido-PEG8-NHS ester is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG8-NHS ester is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

References:
[1]. Mahendra Persaud Deonarain, et al. Biological materials and uses thereof. WO2016046574A1.
[2]. Rong Yuan, et al. Viruslike Element-Tagged Nanoparticle Inductively Coupled Plasma Mass Spectrometry Signal Multiplier: Membrane Biomarker Mediated Cell Counting. Analytical Chemistry (Washington, DC, United States) (2019), 91(8), 4948-4952.