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DBCO-C6-acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DBCO-C6-acid图片
CAS NO:1425485-72-8
包装:25mg
市场价:3150元

产品介绍
DBCO-C6-acid 是一种不可降解 (non-cleavable) 的 ADC linker,用于抗体偶联药物 (ADCs) 的合成。DBCO-C6-acid 可用于合成 carmaphycin 类似物。
Cas No.1425485-72-8
Canonical SMILESO=C(CCCCC(O)=O)N1CC2=C(C=CC=C2)C#CC3=C1C=CC=C3
分子式C21H19NO3
分子量333.38
溶解度DMSO : 100 mg/mL (299.96 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DBCO-C6-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-C6-acid can be used in the synthesis of carmaphycin analogues[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

References:
[1]. Almaliti J, et al. Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents.