您好，欢迎来到试剂仪器网！ [登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > Bis-aminooxy-PEG1
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Bis-aminooxy-PEG1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Bis-aminooxy-PEG1图片
CAS NO:93460-33-4
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Bis-aminooxy-PEG1 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。
Cas No.93460-33-4
Canonical SMILESNOCCOCCON
分子式C4H12N2O3
分子量136.15
储存条件-20°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Bis-aminooxy-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References:
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562