| CAS NO: | 457961-34-1 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 457961-34-1 |
| Canonical SMILES | O=S(N1CCCCC1)(C2=CC=C(OC)C(C)=C2)=O |
| 分子式 | C13H19NO3S |
| 分子量 | 269.36 |
| 溶解度 | DMSO : 250 mg/mL (928.13 mM) |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | AA92593 is a selective and competitive OPN4 (melanopsin) antagonist[1][2]. AA92593 is a competitive melanopsin antagonist, its presence in the retinal-binding pocket of melanopsin leads to the displacement of retinal, which could trigger a downstream signaling that would ultimately result in Per1 increased expression[1].AA92593 is shown to be specific because it competes with retinaldehyde for the melanopsin retinal binding site which is very distinct from other opsins[1].Inhibition of melanopsin activity with AA92593 increases a-MSH expression and induces melanin dispersion in the melanophores, which darkens the embryo[3].AA92593 exhibits an IC50 of 665 nM in CHOOpn4 cells[4]. AA92593 is able to decrease IOP in rabbits living under normal light condition[2].AA92593 produces an increment in melatonin levels resulting in a drop of IOP[2]. References: |
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