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Amino-PEG4-Val-Cit-PAB-MMAE
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Amino-PEG4-Val-Cit-PAB-MMAE图片
CAS NO:1492056-71-9
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Amino-PEG4-Val-Cit-PAB-MMAE 是一种可降解 (cleavable) 的含 4 个单元 PEG 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
Cas No.1492056-71-9
分子式C69H115N11O17
分子量1370.71
溶解度DMSO : 100 mg/mL (72.95 mM; Need ultrasonic)
储存条件Store at -20°C, sealed storage, away from moisture and light,unstable in solution, ready to use.
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Amino-PEG4-Val-Cit-PAB-MMAE is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.