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m-PEG8-Amine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
m-PEG8-Amine图片
CAS NO:869718-81-0
包装:50mg
市场价:450元

产品介绍
m-PEG8-Amine 是一种可降解 (cleavable) 的 ADC linker,用于抗体偶联药物 (ADCs) 的合成。
Cas No.869718-81-0
别名3,6,9,12,15,18,21,24-八氧杂二十五烷-1-胺
分子式C17H37NO8
分子量383.48
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

m-PEG8-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Joshua D. Thoma, et al. Pyrrolobenzodiazepine antibody conjugates. WO2019126691A1.