DC-05 是一种DNMT1的抑制剂，IC50和Kd值分别为 10.3 和 1.09 μM。

DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).

DC-05 is a non-nucleoside DNMT1 inhibitor with low micromolar IC50 values and significant selectivity toward other AdoMet-dependent protein methyltransferases.?DC-05 (1.25, 2.5, 5, and 10 μM) effectively inhibits the proliferation of HCT116 (human colon cancer) and Capan-1 (human pancreatic adenocarcinoma cells) after treatment for 24, 48, and 72 h. DC-05 displays poor potent activities against DNMT3A, DNMT3B, G9a, SUV39H1, MLL1, SET7/9, and PRMT1 (IC50: >200, >200, >150, >150, >150, >150, 37.1 μM) [1].

890643-16-0

C25H25N3O

383.49

DMSO:100 mg/mL (260.76 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years