M-110 是一种高选择性的，ATP 竞争性的 Pim 激酶抑制剂，M-110 对 Pim-3 抑制作用最好，IC50=47 nM。M-110 抑制 Pim-1 和 Pim-2 的IC50 为 2.5 μM。M-110 抑制前列腺癌细胞的增殖，IC50 为 0.6-0.9 μM。

M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases with a preference for PIM-3 (IC50=47 nM). M-110 inhibits PIM-1 and PIM-2 with similar IC50s of 2.5 μM. M-110 inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 μM.

M-110 has no activity on normal human peripheral blood mononuclear cells up to 40 μM. M-110 inhibits the expression of active STAT3 through inhibition of PIM-3. M-110 also inhibits the proliferation of 22Rv1, PC3, and SW480 cells, with IC50 values of 0.6 to 0.8 μM. M-110 (0.01-10 μM; 72 hours) inhibiting the growth of DU-145 cells (IC50: 0.9 μM). M-110 (10 μM; 18 hours) inhibits STAT3 Tyr705 phosphorylation[1].

1395048-49-3

C22H28ClN5O3

445.94

DMSO:31.5mg/mL (70.6mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years