K00135 是 Pim 激酶的选择性抑制剂，可用于胃癌和抗白血病治疗的研究。

K00135 is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.

K00135 dose-dependently impairs the survival of murine Ba/F3 cells that have been rendered cytokine independent by overexpression of human PIMs. K00135 impairs survival and clonogenic growth of a panel of human acute leukemia cells. Exposure of K00135 significantly suppresses in vitro growth of leukemic blasts from five acute myelogenous leukemia patients but not of normal umbilical cord blood mononuclear cells[3].

869650-21-5

C18H18N4O

306.36

Imidazol[1,2-b]pyridazine 1;K-00135;K 00135;IMIDAZOPYRIDAZIN 1

DMSO:soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years