CK2/ERK8-IN-1 是一种酪蛋白激酶 2 (CK2) (Ki 为 0.25 μM) 和 ERK8 (MAPK15, ERK7) 的双重抑制剂，IC50 均为 0.50 μM。CK2/ERK8-IN-1 也与 Pim1，HIPK2 和 DYRK1A 结合，Ki 值分别为 8.65 μM，15.25 μM 和 11.9 μM。

CK2/ERK8-IN-1 is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 μM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1, DYRK1A, and HIPK2 (Kis: 8.65 μM, 11.9 μM, and 15.25 μM).

In Jurkat cells, CK2/ERK8-IN-1 (Compound K66; 0-50 μM; 24 hours) treatment displays cytotoxic activity[1].

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C11H9Br4N3O2

534.82

TMCB

DMSO:16 mg/mL (29.9 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years