Pim-1/2 kinase inhibitor 1 是一种具有口服活性的 Pim-1/2 激酶抑制剂。Pim-1/2 kinase inhibitor 1 能阻断Pim激酶磷酸化肽的能力，并且抑制4E-BP1和p27Kip1的Pim蛋白激酶定向磷酸化。Pim-1/2 kinase inhibitor 1 可用于癌症，尤其是前列腺癌的研究。

Pim-1/2 kinase inhibitor 1 is an orally active pim-1/2 kinase inhibitor. Pim-1/2 kinase inhibitor 1 blocks the ability of Pim kinases to phosphorylate peptides, and inhibits the pim protein kinase directed phosphorylation of 4E-BP1 and p27 Kip1. Pim-1/2 kinase inhibitor 1 can be used in the cancer research, especially prostate cancer [1].

Pim-1/2 kinase inhibitor 1 (compound D14) (varying concentrations; 48 h) exhibits cytotoxicity to PC3 cells, with an IC of 11 μM [1]. Cell Cytotoxicity Assay [1] Cell Line: PC3 cells Concentration: varying concentrations Incubation Time: 48 h Result: Inhibited PC3 cells with an IC of 11 μM.

6320-51-0

C11H9NO3S

235.26

DMSO:225mg/mL (956.4mM),ultrasonic and warming and heat to 60°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years