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N-Boc-PEG2-bromide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
N-Boc-PEG2-bromide图片
CAS NO:164332-88-1
包装:100mg
市场价:810元

产品介绍
N-Boc-PEG2-bromide 是一种 PROTAC 连接桥，属于 PEG 类和 Alkyl/ether 类。N-Boc-PEG2-bromide 可用于合成一系列 PROTAC 分子。N-Boc-PEG2-bromide 是一种可降解 (cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。
Cas No.164332-88-1
别名叔丁氧羰基-二聚乙二醇-溴代
分子式C9H18BrNO3
分子量268.15
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

N-Boc-PEG2-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG2-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[1]. Ruben HERRENDORFF, et al. Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids. WO2017046172A1.