| CAS NO: | 61718-82-9 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| Molecular Weight (MW) | 434.41 |
|---|---|
| Formula | C14H18F3N2O2.C4H4O4 |
| CAS No. | 61718-82-9 (maleate); |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 87 mg/mL (200.3 mM) |
| Water: <1 mg/mL | |
| Ethanol: 87 mg/mL (200.3 mM) | |
| Solubility (In vivo) | Chemical Name: 2-[(E)-[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine maleate InChi Key: LFMYNZPAVPMEGP-PIDGMYBPSA-N InChi Code: InChI=1S/C15H21F3N2O2.C4H4O4/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18;5-3(6)1-2-4(7)8/h5-8H,2-4,9-11,19H2,1H3;1-2H,(H,5,6)(H,7,8)/b20-14+;2-1- SMILES Code: FC(C1=CC=C(/C(CCCCOC)=N/OCCN)C=C1)(F)F.O=C(O)/C=C\C(O)=O |
| Synonyms | DU-23000 maleate; Fluvoxamine maleate, DU 23000; MK264; MK 264; DU23000; Faverin, Fevarin, Floxyfral, Luvox; MK-264; |
| In Vitro | In vitro activity: Fluvoxamine increases [5-HT]ex levels in rat the prefrontal cortex and thalamus, and also increases [DA]ex levels in the striatum. Fluvoxamine maleate ameliorates tactile allodynia via spinal 5-HT2A/2C receptors, by acting on the receptors or 5-HT neurons. |
|---|---|
| In Vivo | Fluvoxamine maleate also exhibits the antinociception in a dose-dependent manner in the paw pressure test in non-ligated mice. Fluvoxamine maleate also induces antinociceptive effect in the acute paw pressure test, and this effect is antagonized by the 5-HT3 receptor antagonist granisetron. Fluvoxamine (10 and 30 mg/kg, i.p.) enhances synaptic efficacy in the hippocampo-mPFC pathway in a dose-dependent manner in the rat hippocampo-medial prefrontal cortex (mPFC). Fluvoxamine (10 and 30 mg/kg, i.p.) suppresses long-term potentiation (LTP) in the hippocampal CA1 field of anesthetized rats. Fluvoxamine (30 mg/kg, i.p.)-induced suppression of LTP is completely reversed by the 5-HT(1A) receptor antagonist NAN-190 (0.5 mg/kg, i.p), but not by the 5-HT(4) receptor antagonist GR 113808 (20 mg/rat, i.c.v.) and the 5-HT(7) receptor antagonist DR 4004 (10 mg/rat, i.c.v.). Fluvoxamine maleate reinforces the response to norepinephrine of isolated rat vas deferens incubated in Krebs-Henseleit solution. Fluvoxamine maleate and Fluoxetine hydrochloride inhibit the contraction induced by potassium ion on the isolated rat uterus preparation with IC50 of 3.99μM and 18.2μM, respectively. |
| Animal model | Non-ligated mice |
| Formulation & Dosage | 10 and 30 mg/kg, i.p. |
| References | Psychopharmacology (Berl). 2004 Nov;176(2):195-203; Neuropharmacology. 2006 Sep;51(4):866-72. |
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