EnaroduSTAT 是口服具有活力的hypoxia-inducible factor prolyl Hydroxylase抑制剂，EC50=0.22 μM，有用于肾性贫血症的研究潜力。

Enarodustat is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.

Enarodustat exhibits neither CYP (IC50 >100 μM; CYP3A4/5, CYP2C9, CYP2D6, CYP1A2, CYP2A6, CYP2C19, CYP2C8, CYP2B6) nor hERG (IC50 >100 μM) inhibition.

Enarodustat (1 and 3 mg/kg, p.o., in rats) treatment increases hemoglobin levels in a dose-dependent manner.

1262132-81-9

C17H16N4O4

340.33

JTZ-951

DMSO:83.33 mg/mL (244.85 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years