Demethyleneberberine 是从黄连中提取的一种天然产物，是线粒体靶向抗氧化剂。它也可作为AMPK激活剂，用于非酒精性脂肪性肝病的研究。它通过抑制NF-Κb通路和调节 Th 细胞的平衡来减轻小鼠结肠炎并抑制炎症反应。

Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either in vitro or in vivo.Demethyleneberberine suppresses CYP2E1, hypoxia inducible factor α, and inducible nitric oxide synthase, which contributes to oxidative stress and restored sirtuin 1/AMP-activated protein kinase/peroxisome proliferator-activated receptor-γ coactivator-1α pathway-associated fatty acid oxidation in chronic ethanol-fed mice.

25459-91-0

C19H18NO4

324.355

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years