2,4-DPD是氧感应酶 HIF-α 脯氨酰羟化酶 (HIF-PH) 的竞争性抑制剂。

2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)

2,4-DPD inhibits the hydroxylation of P564 by acting as a competitive inhibitor of the HIF-PH cofactor α-keto glutarate, with effective concentrations in the low μM range

41438-38-4

C11H13NO4

223.228

DMSO:20mg/ml(89.6 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years