BIBF 1202是BIBF 1120的羧酸盐代谢物。BIBF 1202抑制VEGFR2激酶的IC50值为62 nM。

BIBF 1202 is a VEGFR2 kinase inhibitor (IC50 = 62 nM).

The major metabolic pathway for BIBF 1120 is methyl ester cleavage to BIBF 1202. Then, the free carboxyl group of BIBF 1202 is glucuronidated to 1-O-acyl glucuronide [2].

894783-71-2

C30H31N5O4

525.6

DMSO:40 mg/mL (76.1 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years