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NF-κβ activator 2
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
NF-κβ activator 2图片
CAS NO:2375281-44-8
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
NF-κ；β；激活剂 2 抑制 TNF-α-诱导的经典 NF-κB 信号在 PC-3 细胞中。
Cas No.2375281-44-8
别名3-(2-((2-氟苯基)氨基)恶唑-5-基)苯甲酸
分子式C16H11FN2O3
分子量298.27
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NF-κβ activator 2 is a potent and orally active NF-?B activator, with an EC50 of 1.58 μM. NF-κβ activator 2 induces SOD2 through increasing NF-?B expression and activation. NF-κβ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS)[1].

NF-κβ activator 2 (compound 61) (1 μM, 6 h) induces SOD2 mRNA expression in SH-SY5Y neuroblastoma cells[1].

NF-κβ activator 2 (1 mg/kg; i.v.) displays a suitable half-life (0.96 h) in mice[1].NF-κβ activator 2 (5 mg/kg; p.o.) displays a comparable half-life (2.86 h), oral bioavailability (15.6%), and Cmax (92 ng/mL)[1].

[1]. Mathew B, et, al. Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-?B activators for the treatment of ALS. Eur J Med Chem. 2020 Oct 22;112952.