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m-PEG7-thiol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
m-PEG7-thiol图片
CAS NO:651042-82-9
包装与价格:
包装价格(元)
50mg电议
100mg电议
500mg电议

产品介绍
m-PEG7-thiol 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。
Cas No.651042-82-9
别名2,5,8,11,14,17,20-七氧杂二十二烷-22-硫醇
分子式C15H32O7S
分子量356.48
溶解度DMSO : 100 mg/mL (280.52 mM; Need ultrasonic)
储存条件4°C, protect from light, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

m-PEG7-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562