PF-05231023 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 的合成分子。

PF-05231023 is a long-acting fibroblast growth factor 21 (FGF21) analog and is an FGF21-receptor agonist. It is also suitable for development as a potential treatment for T2DM.

PF-05231023 is a analog of long-acting fibroblast growth factor 21 [2].

PF-05231023 suppresses oxidative-stress-induced inflammation in photoreceptors. PF-05231023 decreases the variability of retinal NRF2 levels and displays a trend (non-significant) towards increased NRF2 levels in Akita mice. PF-05231023 decreases retinal IL-1β mRNA expression in Akita mice. PF-05231023 enhances cone-specific arrestin4 expression in Akita mice. PF-05231023 restores photoreceptor morphology in Akita mice. Administration of native FGF21 and PF-05231023 (3?mg/kg or 10?mg/kg; subcutaneously twice a week for two weeks) improves glucose tolerance and liver insulin sensitivity in Zucker rats. PF-05231023 (10 mg/kg; intraperitoneally injected) reduces retinal inflammation in diabetic mice [3][4].

1037589-69-7

C26H32N4O8

528.55

PF-05231023

DMSO:125 mg/mL (236.50 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years