| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 分子式 | C41H43ClN8O5 |
| 分子量 | 763.28 |
| 溶解度 | DMSO : 85 mg/mL (111.36 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C, sealed storage, away from moisture and light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | ARD-2585 is an exceptionally potent and orally active PROTAC degrader of androgen receptor[1]. ARD-2585 achieves DC50 values of 0.04-0.1 nM in the VCaP cell line with AR gene amplification and in the LNCaP cell line carrying an AR mutation[1].ARD-2585 (100 nM) is effective in reducing the AR protein level at the 3 and 24 h time-points by 78% (p 0.05)[1]. [1]. Weiguo Xiang. et al. Discovery of ARD-2585 as an Exceptionally Potent and Orally Active PROTAC Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer. J Med Chem. 2021 Sep 23;64(18):13487-13509. |
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