ICA-105574 是HERG通道激活剂。它通过消除 HERG 通道的失活从而增强HERG 通道活性。它可以把电流幅度急剧增加到原来的 10 倍以上，其EC50值为 0.5 +/- 0.1 μM，Hill 斜率 (n(H)) 为 3.3 +/- 0.2。

ICA-105574 is an activator of hERG that binds to the channel to remove inactivation, thus increasing peak current amplitude and shortening the action potential. It also modulates activation kinetics of the channel.

316146-57-3

C19H14N2O4

334.331

3-nitro-N-[4-phenoxyphenyl]-benzamide;ICA

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years