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BRL-54443
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BRL-54443图片
CAS NO:57477-39-1
规格:≥98%
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)230.31
FormulaC14H18N2O
CAS No.57477-39-1
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 46 mg/mL (199.7 mM)
Water: <1 mg/mL
Ethanol: 2 mg/mL (8.7 mM)
Solubility (In vivo)30% Propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL
SynonymsBRL 54443; BRL54443; BRL-54443
实验参考方法
In Vitro

In vitro activity: BRL 54443 has also measurable affinity for the 5-HT2A receptor. BRL 54443 induces contraction with a –logEC50 of 6.52. Contraction caused by BRL 54443 is likely mediated through stimulation of 5-HT5-HT2A receptors.

In VivoBRL 54443 induces an immediate dose-dependent maximal intragastric volume increase vs. saline.
Animal modelAdult male cats
Formulation & DosageDissolved in distilled water containing 1 equivalent 2,3-dihydroxybutanedioic acid+0.9% NaCl; 3 μg/kg-30 mg/kg; s.c.injection
References

Eur J Pharmacol. 2004 May 25;492(2-3):259-67; J Pharmacol Exp Ther. 2001 Apr;297(1):88-95.