| CAS NO: | 1158264-69-7 |
| 包装 | 价格(元) |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 1158264-69-7 |
| 别名 | 3-(6-氨基亚甲基-3-氧代-1H-异吲哚-2-基)哌啶-2,6-二酮盐酸盐 |
| 分子式 | C14H16ClN3O3 |
| 分子量 | 309.75 |
| 溶解度 | DMSO : 16.67 mg/mL (53.82 mM; ultrasonic and warming and heat to 60℃) |
| 储存条件 | Store at -20°C, stored under nitrogen |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Lenalidomide-5-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC[1] PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. [1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. |
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