NF023 hexasodium 是具有选择性的、竞争性的 P2X1 受体拮抗剂，其对人 P2X1、P2X3、P2X2 和 P2X4 的 IC50 值分别为 0.21 μM、28.9 μM、>50 μM 和>100 μM。

NF023 hexasodium is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, >50 μM and >100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively.

NF023 is selective for recombinant Gi alpha-1 and recombinant Go alpha (EC50 value of approximately 300 nM)[2]. NF023 inhibits P2X1 receptors in a voltage-insensitive manner. NF023 (5 and 30 μM) causes a shift of the concentration-response curve to the right without affecting the maximal response to ATP (KB=1.190.2 μM)[4].

NF023 (100 μmol/kg i.v.) antagonizes vasopressor responses to α,β-mATP but not to noradrenaline In pithed rats[3].

104869-31-0

C35H20N4Na6O21S6

1168.92

NF 023 hexasodium

H2O:105.3mg/mL (90.1mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years